Research Research Highlights
Research Highlights
Research Highlights
Research Highlights
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First to Uncover What Happens to mRNA Vaccines in the Body
Prof. V. Narry Kim
A Korean research team has, for the first time globally, elucidated the intracellular mechanisms by which mRNA vaccines function, marking a significant advancement in RNA-based therapeutics.
Research Highlights Board

Single-Benzene Dual-Emitters Harness Excited-State Antiaromaticity for White Light Generation and Fluorescence Imaging
Prof. Dongwhan Lee
Single-benzene dual-emitters are realized by proton transfer equilibrium between two emissive tautomers. We demonstrate that the excited-state antiaromaticity of the benzene core drives the proton movements.

Changes in high-density lipoprotein cholesterol with risk of Cardiovascular Disease among initially high-density lipoprotein-high participants
Prof. Sang Min Park
High-density lipoprotein cholesterol (HDL-C) levels were previously considered to be inversely associated with a higher risk of cardiovascular disease (CVD).

Monolithic 100% Silicon Anode for All-Solid-State Batteries Achieving High Areal Capacity at Room Temperature
Prof. Jongwoo Lim
Silicon is an attractive anode material for all-solid-state batteries (ASSBs) because it has a high energy density and is safer than metallic lithium.

Dissecting the Terra-LUNA crash: Evidence from the spillover effect and information flow
Prof. Jaewook Lee
The Terra-LUNA crash in May 2022 was triggered by the depeg of the ecosystem’s stablecoin UST. It led to the unprecedented demise of a blockchain ecosystem and cost investors tens of billions of dollars.

Thermal characteristics of crystalline and amorphous 2′-fucosyllactose, a human milk oligosaccharide
Prof. Donghwa Chung
The thermal characteristics of crystalline and amorphous forms of a human milk oligosaccharide, 2ʹ-fucosyllactose (2ʹ-FL), were investigated by differential scanning calorimetry and thermogravimetric analysis, and compared with the two forms of α-lactose monohydrate.

Comparable humoral and cellular immunity against Omicron variant BA.4/5 of once-boosted BA.1/2 convalescents and twice-boosted COVID-19-naïve individuals
Prof. Myoung-Don Oh, Prof. Hang-Rae Kim, Prof. Hyun Mu Shin, Prof. Chang-Han Lee
The fourth vaccination dose confers additional protective immunity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in individuals with no prior coronavirus disease-19 (COVID-19).

Underlying Role of Hydrophobic Environments in Tuning Metal Elements for Efficient Enzyme Catalysis
Prof. Woon Ju Song
The catalytic functions of metalloenzymes are often strongly correlated with metal elements in the active sites. However, dioxygen-activating nonheme quercetin dioxygenases (QueD) are found with various first-row transition-metal ions when metal swapping inactivates their innate catalytic activity.

Lysosomal control of senescence and inflammation through cholesterol partitioning
Prof. Chanhee Kang
Whereas cholesterol is vital for cell growth, proliferation, and remodeling, dysregulation of cholesterol metabolism is associated with multiple age-related pathologies. Here we show that senescent cells accumulate cholesterol in lysosomes to maintain the senescence-associated secretory phenotype (SASP).

Photocatalytic C–O coupling enzymes that operate via intramolecular electron transfer
Prof. Woon Ju Song
Efficient and environmentally friendly conversion of light energy for direct utilization in chemical production has been a long-standing goal in enzyme design.

Sequence determinant of small RNA production by DICER
Prof. V. Narry Kim
RNA silencing relies on specific and efficient processing of double-stranded RNA by Dicer, which yields microRNAs (miRNAs) and small interfering RNAs (siRNAs).

Suppression of cuticular wax biosynthesis mediated by rice LOV KELCH REPEAT PROTEIN 2 supports a negative role in drought stress tolerance
Prof. Nam-Chon Paek
Drought tolerance is important for grain crops, including rice (Oryza sativa); for example, rice cultivated under intermittent irrigation produces less methane gas compared to rice grown in anaerobic paddy field conditions, but these plants require greater drought tolerance.

Cucurbitacin and volatile compound profiling reveals independent domestication of cucumber (Cucumis sativus L.) fruit
Prof. Eun Jin Lee
Cucurbitacins and volatile compounds of cucumber fruit of 69 genotypes were profiled. Cucurbitacin C was only detected, while other types were not detected. Distinct genotype traits were classified into four groups based on compound profiles. Volatile compounds in F1 hybrids were lower than those in parents and mid-parents.