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Research Highlights

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Research Highlights

Temporally Distinct 3D Multi-Omic Dynamics in the Developing Human Brain

Temporally Distinct 3D Multi-Omic Dynamics in the Developing Human Brain

Prof. Dong-Sung Lee

Professor Dongsung Lee from the College of Medicine at SNU, in collaboration with researchers at UCLA and UCSF, has published a paper in Nature, being the first in the world to study epigenomic changes, including the three-dimensional genome structure and DNA methylation, during human brain development from the fetal stage to adulthood at the single-cell level, using the single-nucleus methyl-3C technology they developed.

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Biophysical impacts of northern vegetation changes on seasonal warming patterns

Biophysical impacts of northern vegetation changes on seasonal warming patterns

Prof. Sujong Jeong

The seasonal greening of Northern Hemisphere (NH) ecosystems, due to extended growing periods and enhanced photosynthetic activity, could modify near-surface warming by perturbing land-atmosphere energy exchanges, yet this biophysical control on warming seasonality is underexplored.

Mechanochemistry-driven engineering of 0D/3D heterostructure for designing highly luminescent Cs–Pb–Br perovskites

Mechanochemistry-driven engineering of 0D/3D heterostructure for designing highly luminescent Cs–Pb–Br perovskites

Prof. Takhee Lee

Embedding metal-halide perovskite particles within an insulating host matrix has proven to be an effective strategy for revealing the outstanding luminescence properties of perovskites as an emerging class of light emitters.

Macaque Clonal Hematopoiesis Model Demonstrates Expansion of TET2-Disrupted Clones and Utility for Testing Interventions

Macaque Clonal Hematopoiesis Model Demonstrates Expansion of TET2-Disrupted Clones and Utility for Testing Interventions

Prof. Kyung-Rok Yu

Individuals with age-related clonal hematopoiesis (CH) are at greater risk for hematologic malignancies and cardiovascular diseases. However, predictive preclinical animal models to recapitulate the spectrum of human CH are lacking.

Graphene-Based Intrinsically Stretchable 2D-Contact Electrodes for Highly Efficient Organic Light-Emitting Diodes

Graphene-Based Intrinsically Stretchable 2D-Contact Electrodes for Highly Efficient Organic Light-Emitting Diodes

Prof. Tae-Woo Lee

Intrinsically stretchable organic light-emitting diodes (ISOLEDs) are becoming essential components of wearable electronics. However, the efficiencies of ISOLEDs have been highly inferior compared with their rigid counterparts, which is due to the lack of ideal stretchable electrode materials that can overcome the poor charge injection at 1D metallic nanowire/organic interfaces.

Targeted erasing of DNA methylation by TET3 drives adipogenic reprogramming and differentiation

Targeted erasing of DNA methylation by TET3 drives adipogenic reprogramming and differentiation

Prof. Jae Bum Kim

DNA methylation is a crucial epigenetic modification in the establishment of cell-type-specific characteristics. However, how DNA methylation is selectively reprogrammed at adipocyte-specific loci during adipogenesis remains unclear.

Essential cues of engineered polymeric materials regulating gene transfer pathways

Essential cues of engineered polymeric materials regulating gene transfer pathways

Prof. Cheol-Heui Yun & Prof. Chong-Su Cho

Regulating cellular uptake pathways using engineered materials is becoming a vital strategy for efficient gene transfer because the success of gene delivery most often relies on the uptake mechanism and the intracellular fate of the delivery vectors.

MSD2-mediated ROS metabolism fine-tunes the timing of floral organ abscission in Arabidopsis

MSD2-mediated ROS metabolism fine-tunes the timing of floral organ abscission in Arabidopsis

Prof. Yuree Lee

The timely removal of end-of-purpose flowering organs is as essential for reproduction and plant survival as timely flowering. Despite much progress in understanding the molecular mechanisms of floral organ abscission, little is known about how various environmental factors are integrated into developmental programmes that determine the timing of abscission.

Admixture of divergent genomes facilitates hybridization across species in the family Brassicaceae

Admixture of divergent genomes facilitates hybridization across species in the family Brassicaceae

Prof. Jin Hoe Huh

Hybridization and polyploidization are pivotal to plant evolution. Genetic crosses between distantly related species are rare in nature due to reproductive barriers but how such hurdles can be overcome is largely unknown.

Complex regulatory networks of virulence factors in Vibrio vulnificus

Complex regulatory networks of virulence factors in Vibrio vulnificus

Prof. Sang Ho Choi

Vibrio vulnificus produces various virulence factors that enhance its fitness in changing environments as well as host cell-damaging activities and inflammatory responses during infection.

CXCL5 inhibits excessive oxidative stress by regulating white adipocyte differentiation

CXCL5 inhibits excessive oxidative stress by regulating white adipocyte differentiation

Prof. Je-Yoel Cho

Chemokines have been well-documented as a major factor in immune cell migration and the regulation of immune responses.

Dynamic interaction of BRCA2 with telomeric G-quadruplexes underlies telomere replication homeostasis

Dynamic interaction of BRCA2 with telomeric G-quadruplexes underlies telomere replication homeostasis

Prof. Hyunsook Lee & Prof. Seong Keun Kim

BRCA2-deficient cells precipitate telomere shortening upon collapse of stalled replication forks. Here, we report that the dynamic interaction between BRCA2 and telomeric G-quadruplex (G4), the non-canonical four-stranded secondary structure, underlies telomere replication homeostasis.

Digital selective transformation and patterning of highly conductive hydrogel bioelectronics by laser-induced phase separation

Digital selective transformation and patterning of highly conductive hydrogel bioelectronics by laser-induced phase separation

Prof. Seung Hwan Ko

The patterning of poly(3,4-ethylenedioxythiophene):poly(styrene sulfonate) (PEDOT:PSS) hydrogels with excellent electrical property and spatial resolution is a challenge for bioelectronic applications.