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Research Highlights

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Research Highlights

Temporally Distinct 3D Multi-Omic Dynamics in the Developing Human Brain

Temporally Distinct 3D Multi-Omic Dynamics in the Developing Human Brain

Prof. Dong-Sung Lee

Professor Dongsung Lee from the College of Medicine at SNU, in collaboration with researchers at UCLA and UCSF, has published a paper in Nature, being the first in the world to study epigenomic changes, including the three-dimensional genome structure and DNA methylation, during human brain development from the fetal stage to adulthood at the single-cell level, using the single-nucleus methyl-3C technology they developed.

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SAIGE-GENE+ improves the efficiency and accuracy of set-based rare variant association tests

SAIGE-GENE+ improves the efficiency and accuracy of set-based rare variant association tests

Prof. Seunggeun Lee

Several biobanks, including UK Biobank (UKBB), are generating large-scale sequencing data. An existing method, SAIGE-GENE, performs well when testing variants with minor allele frequency (MAF) ≤ 1%, but inflation is observed in variance component set-based tests when restricting to variants with MAF ≤ 0.1% or 0.01%.

Reduced dopant-induced scattering in remote charge–transfer-doped MoS2 field-effect transistors

Reduced dopant-induced scattering in remote charge–transfer-doped MoS2 field-effect transistors

Prof. Takhee Lee

Efficient doping for modulating electrical properties of two-dimensional (2D) transition metal dichalcogenide (TMDC) semiconductors is essential for meeting the versatile requirements for future electronic and optoelectronic devices.

Genome-wide association analyses of physical activity and sedentary behavior provide insights into underlying mechanisms and roles in disease prevention

Genome-wide association analyses of physical activity and sedentary behavior provide insights into underlying mechanisms and roles in disease prevention

Prof. Taesung Park

Although physical activity and sedentary behavior are moderately heritable, little is known about the mechanisms that influence these traits.

A sustained high-temperature fusion plasma regime facilitated by fast ions

A sustained high-temperature fusion plasma regime facilitated by fast ions

Prof. Yong-Su Na

Nuclear fusion is one of the most attractive alternatives to carbon-dependent energy sources1. Harnessing energy from nuclear fusion in a large reactor scale, however, still presents many scientific challenges despite the many years of research and steady advances in magnetic confinement approaches.

Liver-originated small extracellular vesicles with TM4SF5 target brown adipose tissue for homeostatic glucose clearance

Liver-originated small extracellular vesicles with TM4SF5 target brown adipose tissue for homeostatic glucose clearance

Prof. Jung Weon Lee

Transmembrane 4 L six family member 5 (TM4SF5) is involved in chronic liver disease, although its role in glucose homeostasis remains unknown. TM4SF5 deficiency caused age-dependent glucose (in)tolerance with no link to insulin sensitivity.

A low-power stretchable neuromorphic nerve with proprioceptive feedback

A low-power stretchable neuromorphic nerve with proprioceptive feedback

Prof. Tae-Woo Lee

By relaying neural signals from the motor cortex to muscles, devices for neurorehabilitation can enhance the movement of limbs in which nerves have been damaged as a consequence of injuries affecting the spinal cord or the lower motor neurons.

Toward gasoline vehicles with zero harmful emissions by storing NO at Pd nanoparticle-CeO2 interface during the cold-start period

Toward gasoline vehicles with zero harmful emissions by storing NO at Pd nanoparticle-CeO2 interface during the cold-start period

Prof. Do Heui Kim

Eliminating NO emissions during the cold-start period of a gasoline vehicle. NO abatement by the joint implementation of catalyst and engine functions.

A photonic quantum engine driven by superradiance

A photonic quantum engine driven by superradiance

Prof. Kyungwon An

Performance of nano- and microscale heat engines can be improved with the help of quantum-mechanical phenomena. Recently, heat reservoirs with quantum coherence have been proposed to enhance engine performance beyond the Carnot limit even with a single reservoir.

Non-fluorinated non-solvating cosolvent enabling superior performance of lithium metal negative electrode battery

Non-fluorinated non-solvating cosolvent enabling superior performance of lithium metal negative electrode battery

Prof. Jongwoo Lim

The growth of dendrites on lithium metal electrodes is problematic because it causes irreversible capacity loss and safety hazards. Localised high-concentration electrolytes (LHCEs) can form a mechanically stable solid-electrolyte interphase and prevent uneven growth of lithium metal.

Mechanically Interlocked Gold Nanocatenanes

Mechanically Interlocked Gold Nanocatenanes

Prof. Jwa-Min Nam

The design of nanostructures is often inspired by the geometries of molecular systems. Inspired by mechanically interlocked catenanes, here we report the synthesis of interlocked plasmonic nanochains, starting from triangular gold nanoplates.

Comparative transcriptome and metabolome analyses of four Panax species explore the dynamics of metabolite biosynthesis

Comparative transcriptome and metabolome analyses of four Panax species explore the dynamics of metabolite biosynthesis

Prof. Tae-Jin Yang

The genus Panax in the Araliaceae family has been used as traditional medicinal plants worldwide and is known to biosynthesize ginsenosides and phytosterols. However, genetic variation between Panax species has influenced their biosynthetic pathways is not fully understood.

Gemini-Mediated Self-Disinfecting Surfaces to Address the Contact Transmission of Infectious Diseases

Gemini-Mediated Self-Disinfecting Surfaces to Address the Contact Transmission of Infectious Diseases

Prof. Jinsoo Ahn

According to both the Center for Disease Control and the World Health Organization, contact transmission is the primary transmission route of infectious diseases worldwide. Usually, this is mitigated by a schedule of repeated regular sanitization, yet surfaces are easily re-contaminated in the interim between cleanings.