Research Research Highlights
Research Highlights
Research Highlights
Research Highlights
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First to Uncover What Happens to mRNA Vaccines in the Body
Prof. V. Narry Kim
A Korean research team has, for the first time globally, elucidated the intracellular mechanisms by which mRNA vaccines function, marking a significant advancement in RNA-based therapeutics.
Research Highlights Board

Dynamic surface phases controlling asymmetry of high-rate lithiation and delithiation in phase-separating electrodes
Prof. Jongwoo Lim
Li-ion battery electrodes exhibit a poorly understood resistance increase during high-rate lithiation, which is rarely observed during delithiation. This hysteresis, often attributed to the solid-state diffusion effect, has not been clearly understood.

Glucocorticoid enhances presenilin1-dependent Aβ production at ER's mitochondrial-associated membrane by downregulating Rer1 in neuronal cells
Prof. Ho Jae Han
Stress-induced release of glucocorticoid is an important amyloidogenic factor that upregulates amyloid precursor protein (APP) and β secretase 1 (BACE1) levels. Glucocorticoid also contributes to the pathogenesis of Alzheimer's disease (AD) by increasing ER-mitochondria connectivity, in which amyloid β (Aβ) processing occurs rigorously because of its lipid raft-rich characteristics.

Polystyrene microplastics biodegradation by gut bacterial Enterobacter hormaechei from mealworms under anaerobic conditions: Anaerobic oxidation and depolymerization
Prof. Younghoon Kim
Synthetic plastic is used throughout daily life and industry, threatening organisms with microplastic pollution. Polystyrene is a major plastic polymer and also widely found sources of plastic wastes and microplastics.

Super-resolution proximity labeling reveals antiviral protein network and its structural changes against SARS-CoV-2 viral proteins
Prof. Hyun-Woo Rhee
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) replicates in human cells by interacting with host factors following infection.

Distinct characteristics of two types of alternative lengthening of telomeres in mouse embryonic stem cells
Prof. Junho Lee
Telomere length must be maintained in actively dividing cells to avoid cellular arrest or death.

Scientists unlock the dog epigenome
Prof. Je-Yoel Cho
Researchers have successfully mapped the dog epigenome and created a high-quality reference map driving new understanding and opening new avenues for functional genomics research in dogs and comparative studies with humans and other species.

Optimized superconductivity in the vicinity of a nematic quantum critical point in the kagome superconductor Cs(V1-xTix)3Sb5
Prof. Kee Hoon Kim
CsV3Sb5 exhibits superconductivity at Tc = 3.2 K after undergoing intriguing two high-temperature transitions: charge density wave order at ~98 K and electronic nematic order at Tnem ~ 35 K.

Targeted degradation of α-synuclein aggregates in Parkinson’s disease using the AUTOTAC technology
Prof. Yong Tae Kwon
There are currently no disease-modifying therapeutics for Parkinson’s disease (PD). Although extensive efforts were undertaken to develop therapeutic approaches to delay the symptoms of PD, untreated α-synuclein (α-syn) aggregates cause cellular toxicity and stimulate further disease progression.

TRIM16-mediated lysophagy suppresses high-glucose-accumulated neuronal Aβ
Prof. Ho Jae Han
Lysosomal dysfunction is a pathogenic link that may explain the causal relationship between diabetes and Alzheimer disease; however, there is no information about the regulation of hyperglycemia in neuronal lysophagy modulating lysosomal function.

Ptr1 and ZAR1 immune receptors confer overlapping and distinct bacterial pathogen effector specificities
Prof. Kee Hoon Sohn
Some nucleotide-binding and leucine-rich repeat receptors (NLRs) indirectly detect pathogen effectors by monitoring their host targets.

Harnessing a paper-folding mechanism for reconfigurable DNA origami
Prof. Do-Nyun Kim
Professor Kim Do-Nyun's research team from the Department of Mechanical Engineering at Seoul National University has succeeded in developing DNA nanotechnology, which allows for the folding or unfolding of a single structure into various shapes, harnessing the paper-folding mechanism.