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Research Highlights

Research Highlights /

Research Highlights

Temporally Distinct 3D Multi-Omic Dynamics in the Developing Human Brain

Temporally Distinct 3D Multi-Omic Dynamics in the Developing Human Brain

Prof. Dong-Sung Lee

Professor Dongsung Lee from the College of Medicine at SNU, in collaboration with researchers at UCLA and UCSF, has published a paper in Nature, being the first in the world to study epigenomic changes, including the three-dimensional genome structure and DNA methylation, during human brain development from the fetal stage to adulthood at the single-cell level, using the single-nucleus methyl-3C technology they developed.

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Floatable photocatalytic hydrogel nanocomposites for large-scale solar hydrogen production

Floatable photocatalytic hydrogel nanocomposites for large-scale solar hydrogen production

Prof. Taeghwan Hyeon, Prof. Dae-Hyeong Kim

Storing solar energy in chemical bonds aided by heterogeneous photocatalysis is desirable for sustainable energy conversion. Despite recent progress in designing highly active photocatalysts, inefficient solar energy and mass transfer, the instability of catalysts and reverse reactions impede their practical large-scale applications.

First quantification and chemical characterization of atmospheric microplastics observed in Seoul, South Korea

First quantification and chemical characterization of atmospheric microplastics observed in Seoul, South Korea

Prof. Sujong Jeong

This study is the first report on atmospheric microplastics (MPs) observed in five outdoor environments, including an urban forest, a business center, commercial areas, and a public transportation hub in Seoul, South Korea.

Single-Benzene Dual-Emitters Harness Excited-State Antiaromaticity for White Light Generation and Fluorescence Imaging

Single-Benzene Dual-Emitters Harness Excited-State Antiaromaticity for White Light Generation and Fluorescence Imaging

Prof. Dongwhan Lee

Single-benzene dual-emitters are realized by proton transfer equilibrium between two emissive tautomers. We demonstrate that the excited-state antiaromaticity of the benzene core drives the proton movements.

Changes in high-density lipoprotein cholesterol with risk of Cardiovascular Disease among initially high-density lipoprotein-high participants

Changes in high-density lipoprotein cholesterol with risk of Cardiovascular Disease among initially high-density lipoprotein-high participants

Prof. Sang Min Park

High-density lipoprotein cholesterol (HDL-C) levels were previously considered to be inversely associated with a higher risk of cardiovascular disease (CVD).

Monolithic 100% Silicon Anode for All-Solid-State Batteries Achieving High Areal Capacity at Room Temperature

Monolithic 100% Silicon Anode for All-Solid-State Batteries Achieving High Areal Capacity at Room Temperature

Prof. Jongwoo Lim

Silicon is an attractive anode material for all-solid-state batteries (ASSBs) because it has a high energy density and is safer than metallic lithium.

Dissecting the Terra-LUNA crash: Evidence from the spillover effect and information flow

Dissecting the Terra-LUNA crash: Evidence from the spillover effect and information flow

Prof. Jaewook Lee

The Terra-LUNA crash in May 2022 was triggered by the depeg of the ecosystem’s stablecoin UST. It led to the unprecedented demise of a blockchain ecosystem and cost investors tens of billions of dollars.

Thermal characteristics of crystalline and amorphous 2′-fucosyllactose, a human milk oligosaccharide

Thermal characteristics of crystalline and amorphous 2′-fucosyllactose, a human milk oligosaccharide

Prof. Donghwa Chung

The thermal characteristics of crystalline and amorphous forms of a human milk oligosaccharide, 2ʹ-fucosyllactose (2ʹ-FL), were investigated by differential scanning calorimetry and thermogravimetric analysis, and compared with the two forms of α-lactose monohydrate.

Comparable humoral and cellular immunity against Omicron variant BA.4/5 of once-boosted BA.1/2 convalescents and twice-boosted COVID-19-naïve individuals

Comparable humoral and cellular immunity against Omicron variant BA.4/5 of once-boosted BA.1/2 convalescents and twice-boosted COVID-19-naïve individuals

Prof. Myoung-Don Oh, Prof. Hang-Rae Kim, Prof. Hyun Mu Shin, Prof. Chang-Han Lee

The fourth vaccination dose confers additional protective immunity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in individuals with no prior coronavirus disease-19 (COVID-19).

Underlying Role of Hydrophobic Environments in Tuning Metal Elements for Efficient Enzyme Catalysis

Underlying Role of Hydrophobic Environments in Tuning Metal Elements for Efficient Enzyme Catalysis

Prof. Woon Ju Song

The catalytic functions of metalloenzymes are often strongly correlated with metal elements in the active sites. However, dioxygen-activating nonheme quercetin dioxygenases (QueD) are found with various first-row transition-metal ions when metal swapping inactivates their innate catalytic activity.

Lysosomal control of senescence and inflammation through cholesterol partitioning

Lysosomal control of senescence and inflammation through cholesterol partitioning

Prof. Chanhee Kang

Whereas cholesterol is vital for cell growth, proliferation, and remodeling, dysregulation of cholesterol metabolism is associated with multiple age-related pathologies. Here we show that senescent cells accumulate cholesterol in lysosomes to maintain the senescence-associated secretory phenotype (SASP).

Photocatalytic C–O coupling enzymes that operate via intramolecular electron transfer

Photocatalytic C–O coupling enzymes that operate via intramolecular electron transfer

Prof. Woon Ju Song

Efficient and environmentally friendly conversion of light energy for direct utilization in chemical production has been a long-standing goal in enzyme design.

Sequence determinant of small RNA production by DICER

Sequence determinant of small RNA production by DICER

Prof. V. Narry Kim

RNA silencing relies on specific and efficient processing of double-stranded RNA by Dicer, which yields microRNAs (miRNAs) and small interfering RNAs (siRNAs).