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Research Highlights

Research Highlights /

Research Highlights

Temporally Distinct 3D Multi-Omic Dynamics in the Developing Human Brain

Temporally Distinct 3D Multi-Omic Dynamics in the Developing Human Brain

Prof. Dong-Sung Lee

Professor Dongsung Lee from the College of Medicine at SNU, in collaboration with researchers at UCLA and UCSF, has published a paper in Nature, being the first in the world to study epigenomic changes, including the three-dimensional genome structure and DNA methylation, during human brain development from the fetal stage to adulthood at the single-cell level, using the single-nucleus methyl-3C technology they developed.

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Resonant cavity phosphor

Resonant cavity phosphor

Prof. Heonsu Jeon

Prof. Heonsu Jeon’s research team at SNU has developed a structurally engineered phosphor platform based on simple and compact resonant cavity, which greatly enhances color conversion efficiency, effectively requiring far less phosphor material than the structureless counterpart.

Bioactive and Hemocompatible PLA/Lignin Bio-Composites: Assessment of In-Vitro Antioxidant Activity for Biomedical Applications

Bioactive and Hemocompatible PLA/Lignin Bio-Composites: Assessment of In-Vitro Antioxidant Activity for Biomedical Applications

Prof. Joon Weon Choi

In this study, acetylated soda lignin (ASL) and non-acetylated soda lignin (SL) were extruded with PLA in different concentrations to fabricate antioxidant polylactic acid (PLA)/lignin composites for potential biomedical applications. After lignin acetylation, good compatibility was observed between PLA and lignin in SEM images.

Targeted and Logical Discovery of Piperazic Acid-Bearing Natural Products Based on Genomic and Spectroscopic Signatures

Targeted and Logical Discovery of Piperazic Acid-Bearing Natural Products Based on Genomic and Spectroscopic Signatures

Prof. Dong-Chan Oh

A targeted and logical discovery method was devised for natural products containing piperazic acid (Piz), which is biosynthesized from ornithine by l-ornithine N-hydroxylase (KtzI) and N–N bond formation enzyme (KtzT). Genomic signature-based screening of a bacterial DNA library (2020 strains) using polymerase chain reaction (PCR) primers targeting ktzT identified 62 strains (3.1%).

Agrivoltaic system designing for sustainability and smart farming: Agronomic aspects and design criteria with safety assessment

Agrivoltaic system designing for sustainability and smart farming: Agronomic aspects and design criteria with safety assessment

An agrivoltaic system (AVS) offers a potential strategy for meeting global demands for renewable energy and sustainability by integrating photovoltaics and agriculture.

SNU have reported the formation of zero-twisted fully commensurate van der Waals structure

SNU have reported the formation of zero-twisted fully commensurate van der Waals structure

Prof. Gwan-Hyoung Lee

Professor Gwan-Hyoung Lee's research team from the Department of Materials Science and Engineering at SNU has reported the thermally induced atomic reconstruction into fully commensurate structure of randomly stacked 2D layers.

Palmitic acid aggravates liver cancer progression

Palmitic acid aggravates liver cancer progression

Prof. Yang-Sook Chun

A research team led by Professor Yang-Sook Chun from the Department of Physiology & Biomedical Sciences at SNU has uncovered the molecular mechanism of palmitoylation-driven lipid reprogramming in liver cancer cells.

Adenosine monophosphate enhances callus regeneration competence for de novo plant organogenesis

Adenosine monophosphate enhances callus regeneration competence for de novo plant organogenesis

Prof. Pil Joon Seo

Many crop plants have genetic barriers to de novo organogenesis during tissue culture. Therefore, exogenous application of metabolites and/or small molecules that promote cell fate transition in tissue culture-recalcitrant species could be key solution for current bottlenecks.

Exploring the Diverse Landscape of Biaryl-Containing Peptides Generated by Cytochrome P450 Macrocylcases

Exploring the Diverse Landscape of Biaryl-Containing Peptides Generated by Cytochrome P450 Macrocylcases

Prof. Dong-Chan Oh, and Seokhee Kim

Cytochrome P450 enzymes (P450s) catalyze diverse oxidative cross-coupling reactions between aromatic substrates in natural product biosynthesis.

Proposing New Evolutionary Connections from 214 Million Predicted Protein Structure Database

Proposing New Evolutionary Connections from 214 Million Predicted Protein Structure Database

Prof. Martin Steinegger

Prof. Steinegger‘s team from the Department of Biological Science at SNU has unlocked the gate to the large predicted protein structure AlphaFold Database by clustering the 214M structures into 2M shape-groups, revealing putative homology in prokaryotic species to human immune-related proteins.

Novel pathological mechanism of Alzheimer’s disease uncovered

Novel pathological mechanism of Alzheimer’s disease uncovered

Prof. Min Jae Lee

Professor Lee's group and colleagues from the Department of Biomedical Sciences at SNU College of Medicine have identified a novel pathological mechanism of Alzheimer’s disease, which opens first-in-class therapeutic strategies.

Cortical astrocytes modulate dominance behavior in male mice by regulating synaptic excitatory and inhibitory balance

Cortical astrocytes modulate dominance behavior in male mice by regulating synaptic excitatory and inhibitory balance

Prof. Sung Joong Lee

Social hierarchy is established as an outcome of individual social behaviors, such as dominance behavior during long-term interactions with others. Astrocytes are implicated in optimizing the balance between excitatory and inhibitory (E/I) neuronal activity, which may influence social behavior.

A whole-genome reference panel of 14,393 individuals for East Asian populations accelerates discovery of rare functional variants

A whole-genome reference panel of 14,393 individuals for East Asian populations accelerates discovery of rare functional variants

Prof. Jong-il Kim

Underrepresentation of non-European (EUR) populations hinders growth of global precision medicine. Resources such as imputation reference panels that match the study population are necessary to find low-frequency variants with substantial effects.