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Research Highlights

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Research Highlights

Temporally Distinct 3D Multi-Omic Dynamics in the Developing Human Brain

Temporally Distinct 3D Multi-Omic Dynamics in the Developing Human Brain

Prof. Dong-Sung Lee

Professor Dongsung Lee from the College of Medicine at SNU, in collaboration with researchers at UCLA and UCSF, has published a paper in Nature, being the first in the world to study epigenomic changes, including the three-dimensional genome structure and DNA methylation, during human brain development from the fetal stage to adulthood at the single-cell level, using the single-nucleus methyl-3C technology they developed.

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Molecular characterization of <i>Fusarium venenatum</i>-based microbial protein in animal models of obesity using multi-omics analysis

Molecular characterization of Fusarium venenatum-based microbial protein in animal models of obesity using multi-omics analysis

Prof. Younghoon Kim

Microbial protein, produced by fermentation of Fusarium venenatum is a promising candidate alternative protein source. Previous study has demonstrated its ability to improve hyperlipidemia in rats, yet the related mechanism remains unclear.

Missing methane emissions from urban sewer networks

Missing methane emissions from urban sewer networks

Prof. Sujong Jeong

Methane emissions from sewer networks are an important source of anthropogenic greenhouse gases (GHGs) but are not currently reflected in the national GHG inventory.

Targeting class A GPCRs for hard tissue regeneration

Targeting class A GPCRs for hard tissue regeneration

Prof. Jin Man Kim

This study present a strategy for targeting GPCRs for hard tissue regeneration by promoting the biomineralization of mesenchymal stromal cells. The discovered GPCR-targeting drugs revealed potent regenerative effects in both tooth and bone defects.

IRF1 deficiency predisposes cartilage to accumulate DNA damage and promotes osteoarthritis development

IRF1 deficiency predisposes cartilage to accumulate DNA damage and promotes osteoarthritis development

Prof. Jin-Hong Kim

Interferon regulatory factor 1 (IRF1) is a transcriptional regulator conventionally associated with immunomodulation. Recent molecular analyses mapping DNA binding sites of IRF1 have suggested its potential function in DNA repair.

Deciphering natural and anthropogenic sources of nitrous oxide

Deciphering natural and anthropogenic sources of nitrous oxide

Prof. Jinho Ahn

Nitrous oxide (or nitrous oxide, N2O) is a major greenhouse gas, along with carbon dioxide (CO2) and methane (CH4), and is about 300 times more potent than CO2.

Low temperature-mediated repression and far-red light-mediated induction determine morning <i>FLOWERING LOCUS T</i> expression levels

Low temperature-mediated repression and far-red light-mediated induction determine morning FLOWERING LOCUS T expression levels

Prof. Young Hun Song

In order to flower in the appropriate season, plants monitor light and temperature changes and alter downstream pathways that regulate florigen genes such as Arabidopsis (Arabidopsis thaliana) FLOWERING LOCUS T (FT).

Decoupling NAD<sup>+</sup> metabolic dependency in chondrosarcoma by targeting the SIRT1–HIF-2α axis

Decoupling NAD⁺ metabolic dependency in chondrosarcoma by targeting the SIRT1–HIF-2α axis

Prof. Jin-Hong Kim

Chondrosarcomas represent the second most common primary bone malignancy. Despite the vulnerability of chondrosarcoma cells to nicotinamide adenine dinucleotide (NAD) depletion, targeting the NAD+ synthesis pathway remains challenging due to broad implications in biological processes.

Genomic overview of INA-induced NPR1 targeting and transcriptional cascades in Arabidopsis

Genomic overview of INA-induced NPR1 targeting and transcriptional cascades in Arabidopsis

Prof. Yoo-Sun Noh

The phytohormone salicylic acid (SA) triggers transcriptional reprogramming that leads to SA-induced immunity in plants. NPR1 is an SA receptor and master transcriptional regulator in SA-triggered transcriptional reprogramming.

Seoul National University

Identification of specific neutralizing antibodies for highly pathogenic avian influenza H5 2.3.4.4b clades to facilitate vaccine design and therapeutics

Prof. Seon Ju Yeo

The highly pathogenic avian influenza H5 2.3.4.4 and 2.3.2.1c subclades have distinct antigenic properties and are responsible for the majority of human infections.

Comprehensive characterization of early-programmed tumor microenvironment by tumor-associated macrophages reveals galectin-1 as an immune modulatory target in breast cancer

Comprehensive characterization of early-programmed tumor microenvironment by tumor-associated macrophages reveals galectin-1 as an immune modulatory target in breast cancer

Prof. Seung Hyeok Seok

In recent years, there has been considerable interest in the therapeutic targeting of tumor-associated macrophages (TAMs) to modulate the tumor microenvironment (TME), resulting in antitumoral phenotypes.

Evaluation of future flood probability in agricultural reservoir watersheds using an integrated flood simulation system

Evaluation of future flood probability in agricultural reservoir watersheds using an integrated flood simulation system

Prof. Moon Seong Kang

Prof. Moon Seong Kang and his research team have developed an evaluation method for future flood probability, addressing an agricultural reservoir watershed and the hydraulic structures within.

Variants in the WDR44 WD40-Repeat Domain Cause a Spectrum of Ciliopathy by Impairing Ciliogenesis Initiation

Variants in the WDR44 WD40-Repeat Domain Cause a Spectrum of Ciliopathy by Impairing Ciliogenesis Initiation

Prof. Sung-Gyoo Park and Jong-Hee Chae

Professor Sung-Gyoo Park's research team from the College of Pharmacy at SNU has discovered WDR44 variants that induce human ciliopathy through international collaborative work with researchers from 8 nations.