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Research Highlights

Research Highlights /

Research Highlights

Temporally Distinct 3D Multi-Omic Dynamics in the Developing Human Brain

Temporally Distinct 3D Multi-Omic Dynamics in the Developing Human Brain

Prof. Dong-Sung Lee

Professor Dongsung Lee from the College of Medicine at SNU, in collaboration with researchers at UCLA and UCSF, has published a paper in Nature, being the first in the world to study epigenomic changes, including the three-dimensional genome structure and DNA methylation, during human brain development from the fetal stage to adulthood at the single-cell level, using the single-nucleus methyl-3C technology they developed.

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Sodium butyrate ameliorates high glucose-suppressed neuronal mitophagy by restoring PRKN expression via inhibiting the RELA-HDAC8 complex

Sodium butyrate ameliorates high glucose-suppressed neuronal mitophagy by restoring PRKN expression via inhibiting the RELA-HDAC8 complex

Prof. Ho Jae Han

Damaged mitochondria accumulation in diabetes is one of the main features that contribute to increased incidence of cognitive impairment by inducing apoptosis. Butyrate is a major metabolite produced by microbiota that has neuroprotective effects by regulating mitochondrial function.

Phase patterning of liquid crystal elastomers by laser-induced dynamic crosslinking

Phase patterning of liquid crystal elastomers by laser-induced dynamic crosslinking

Prof. Seung Hwan Ko

Liquid crystal elastomers hold promise in various fields due to their reversible transition of mechanical and optical properties across distinct phases.

Asymmetric hysteresis response of mid-latitude storm tracks to CO<sub>2</sub> removal

Asymmetric hysteresis response of mid-latitude storm tracks to CO₂ removal

Prof. Seok-Woo Son

In a warming climate, storm tracks are projected to intensify on their poleward side. Here we use large-ensemble CO2 ramp-up and ramp-down simulations to show that these changes are not reversed when CO2 concentrations are reduced.

Prediction of DNA origami shape using graph neural network

Prediction of DNA origami shape using graph neural network

Prof. Do-Nyun Kim

Unlike proteins, which have a wealth of validated structural data, experimentally or computationally validated DNA origami datasets are limited. Here we present a graph neural network that can predict the three-dimensional conformation of DNA origami assemblies both rapidly and accurately.

Integrated assessment of the natural purification capacity of tidal flat for persistent toxic substances and heavy metals in contaminated sediments

Integrated assessment of the natural purification capacity of tidal flat for persistent toxic substances and heavy metals in contaminated sediments

Prof. Jong Seong Khim

Natural purification of pollutants is highly recognized as regulating ecosystem services; however, the purification capacity of tidal flats remains largely unknown and/or unquantified.

Molecular Characterization and Environmental Impact of Newly Isolated Lytic Phage SLAM_phiST1N3 in the <i>Cornellvirus</i> Genus for Biocontrol of a multidrug-resistant <i>Salmonella</i> Typhimurium in the Swine Industry chain

Molecular Characterization and Environmental Impact of Newly Isolated Lytic Phage SLAM_phiST1N3 in the Cornellvirus Genus for Biocontrol of a multidrug-resistant Salmonella Typhimurium in the Swine Industry chain

Prof. Younghoon Kim

SNU CALS team led by Prof Younghoon Kim evaluate on the molecular characterization and environmental impact of newly isolated lytic phage SLAM_phiST1N3 in the Cornellvirus genus for biocontrol of a multidrug-resistant Salmonella Typhimurium in the swine industry chain.

Brain hypothyroidism silences the immune response of microglia in Alzheimer’s disease animal model

Brain hypothyroidism silences the immune response of microglia in Alzheimer’s disease animal model

Prof. Inhee Mook-Jung

Alzheimer's disease (AD) accounts for up to 80% of all dementia cases. The striking similarity in cognitive decline symptoms between AD and hypothyroidism is notable observation with numerous reports emphasizing thyroid hormone imbalance in AD patients.

Thermodynamic modulation of gephyrin condensation by inhibitory synapse components

Thermodynamic modulation of gephyrin condensation by inhibitory synapse components

Prof. Yongdae Shin

At neuronal synapses, several dense structures coexist similar to the way oil and water stay as two immiscible liquids. It has been considered that phase separation drives the formation of these dense structures composed of numerous structural and functional proteins.

Associations of cholecystectomy with metabolic health changes and incident cardiovascular disease: a retrospective cohort study

Associations of cholecystectomy with metabolic health changes and incident cardiovascular disease: a retrospective cohort study

Prof. Sang Min Park

Although some studies conducted about the risk of cholecystectomy and cardiovascular disease, there was a limit to explaining the relationship.

Electrically Confined Electroluminescence of Neutral Excitons in WSe2 Light-Emitting Transistors

Electrically Confined Electroluminescence of Neutral Excitons in WSe2 Light-Emitting Transistors

Prof. Gwan-Hyoung Lee

Professor Gwan-Hyoung Lee's research team from the Department of Materials Science and Engineering at SNU has reported the electrically confined electroluminescence of neutral excitons in 2D light-emitting transistors.

Synergistic Effect of Ferroptosis-Inducing Nanoparticles and X-Ray Irradiation Combination Therapy

Synergistic Effect of Ferroptosis-Inducing Nanoparticles and X-Ray Irradiation Combination Therapy

Prof. Kangwon Lee

Professor Kangwon Lee's research team from the Department of Applied Bioengineering at SNU succeeded in identifying the effects of safe combination anti-cancer treatment with X-ray irradiation using ferroptosis-inducing nanoparticles.

Ubiquitin Ligase RNF20 Coordinates Sequential Adipose Thermogenesis with Brown and Beige Fat-Specific Substrates

Ubiquitin Ligase RNF20 Coordinates Sequential Adipose Thermogenesis with Brown and Beige Fat-Specific Substrates

Prof. Jae Bum Kim

In mammals, brown adipose tissue (BAT) and inguinal white adipose tissue (iWAT) execute sequential thermogenesis to maintain body temperature during cold stimuli.