Professor Jin-Hong Kim's research team from School of Biological Sciences at SNU identified the pathogenic role of sugar modification which governs the senescence-associated secretory phenotype in cartilage, and proposed targeting GATA4 O-GlcNAcylation as a senostatic strategy for osteoarthritis.

Dynamic communication between hepatocytes and the environment is critical in hepatocellular carcinoma (HCC) development. Clinical immunotherapy against HCC is currently unsatisfactory and needs more systemic considerations, including the identification of new biomarkers and immune checkpoints.

Professor Dohun Kim's research team from the Department of Physics and Astronomy at SNU has successfully developed two techniques to suppress noise and its effects, which hinder high-fidelity quantum operations. Using these methods, they achieved a two-fold improvement in inhomogeneous coherence time and a ten-fold improvement in the quality of Rabi oscillations.

Seoul National University College of Engineering announced that a research team led by Prof. Seung-Kyun Kang from the Department of Materials Science and Engineering at Seoul National University (first authors: Dr. Jae-Hwan Lee and Ph.D. candidate Yoon-Nam Kim) has developed a strain sensor with record-breaking sensitivity in collaboration with researchers from Dankook University, Ajou University, and Purdue University.

The homochirality of life remains an unresolved scientific question. Prevailing models postulate that homochirality arose through mutual antagonism. In this mechanism, molecules of opposite handedness deactivate each other, amplifying even a small enantiomeric excess into a larger proportion.

The College of Engineering at Seoul National University announced that Professors Jungwon Park and Jaeyune Ryu of the Department of Chemical and Biological Engineering, in collaboration with Hyundai Motor Group, have developed an innovative technology for rapid durability assessment and identification of degradation mechanisms of hydrogen fuel cell catalysts.

The SNU CALS team, led by Prof. Jun-Hyung Tak, has presented a framework to optimize the composition of natural product-based pesticides, maximizing pesticidal activity while minimizing undesirable effects such as ecotoxicity and phytotoxicity.

Overcoming the immunosuppressive tumor microenvironment is a promising strategy in anticancer therapy. L-kynurenine, a strong immunosuppressive metabolite can be degraded through kynureninases.

Tailor-made enzymes empower a wide range of versatile applications, although searching for the desirable enzymes often requires high throughput screening and thus poses significant challenges. In this study, we employed homology searches and protein language models to discover and prioritize enzymes by their kinetic parameters.

The cerebellum is activated by noxious stimuli and pathological pain but its role in noxious information processing remains unknown.

Oral lichen planus (OLP) is a chronic T cell-mediated inflammatory mucosal disease of unknown etiology. The lack of suitable animal models has hampered understanding its etiopathogenesis.

SORT1 (sortilin 1), a member of the the Vps10 (vacuolar protein sorting 10) family, is involved in hepatic lipid metabolism by regulating very low-density lipoprotein (VLDL) secretion and facilitating the lysosomal degradation of CES1 (carboxylesterase 1), crucial for triglyceride (TG) breakdown in the liver.