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Research Highlights

Research Highlights /

Research Highlights

Temporally Distinct 3D Multi-Omic Dynamics in the Developing Human Brain

Temporally Distinct 3D Multi-Omic Dynamics in the Developing Human Brain

Prof. Dong-Sung Lee

Professor Dongsung Lee from the College of Medicine at SNU, in collaboration with researchers at UCLA and UCSF, has published a paper in Nature, being the first in the world to study epigenomic changes, including the three-dimensional genome structure and DNA methylation, during human brain development from the fetal stage to adulthood at the single-cell level, using the single-nucleus methyl-3C technology they developed.

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MXene-enhanced Ionovoltaic Effect by Evaporation and Water Infiltration in Semiconductor Nanochannels

MXene-enhanced Ionovoltaic Effect by Evaporation and Water Infiltration in Semiconductor Nanochannels

Prof. Seung Hwan Ko

Professor Ko's research team from the Department of Mechanical Engineering at SNU has succeeded in developing energy harvesting through water infiltration in semiconductor nanochannels. Additionally, they have efficiently harnessed solar energy using the 2D material MXene, which improves its performance.

Spin angular momentum-encoded single-photon emitters in a chiral nanoparticle-coupled WSe2 monolayer

Spin angular momentum-encoded single-photon emitters in a chiral nanoparticle-coupled WSe2 monolayer

Prof. Hong-Gyu Park

Spin angular momentum-encoded single-photon emitters are basic building blocks for the advancement of chiral quantum optics and cryptography.

3D Printing with a 3D Printed Digital Material Filament for Programming Functional Gradients

3D Printing with a 3D Printed Digital Material Filament for Programming Functional Gradients

Prof. Howon Lee and Kyu-Jin Cho

Additive manufacturing, or 3D printing attracts growing attention as a promising method for creating functionally graded materials.

Metabuli: sensitive and specific metagenomic classification via joint analysis of amino acid and DNA

Metabuli: sensitive and specific metagenomic classification via joint analysis of amino acid and DNA

Prof. Martin Steinegger

Metagenomic taxonomic classifiers analyze either DNA or amino acid (AA) sequences. Metabuli (https://metabuli.steineggerlab.com), however, jointly analyzes both DNA and AA to leverage AA conservation for sensitive homology detection and DNA mutations for specific differentiation of closely related taxa. In the Critical...

Enhancing genome editing in hPSCs through dual inhibition of DNA damage response and repair pathways

Enhancing genome editing in hPSCs through dual inhibition of DNA damage response and repair pathways

Prof. Hyuk-Jin Cha

Precise genome editing is crucial for establishing isogenic human disease models and ex vivo stem cell therapy from the patient-derived hPSCs.

Hypothalamic neuronal activation in non-human primates drives naturalistic goal-directed eating behavior

Hypothalamic neuronal activation in non-human primates drives naturalistic goal-directed eating behavior

Prof. Hyung Jin Choi

Professor choi’s research team from the SNU demonstrated that activation of LHAGABA neurons in non-human primate drives naturalistic goal-directed eating behavior and motivation, predominantly for palatable food.

Optogenetic control of mRNA condensation reveals an intimate link between condensate material properties and functions

Optogenetic control of mRNA condensation reveals an intimate link between condensate material properties and functions

Prof. Yongdae Shin

Biomolecular condensates, often assembled through phase transition mechanisms, play key roles in organizing diverse cellular activities. The material properties of condensates, ranging from liquid droplets to solid-like glasses or gels, are key features impacting the way resident components associate with one another.

Antibiotic-induced intestinal microbiota depletion can attenuate the acute kidney injury to chronic kidney disease transition via NADPH oxidase 2 and trimethylamine-N-oxide inhibition

Antibiotic-induced intestinal microbiota depletion can attenuate the acute kidney injury to chronic kidney disease transition via NADPH oxidase 2 and trimethylamine-N-oxide inhibition

Prof. Jung Pyo Lee, Seung Hee Yang

Intestinal microbiota and their metabolites affect systemic inflammation and kidney disease outcomes. Here, we investigated the key metabolites associated with the acute kidney injury (AKI)-to chronic kidney disease (CKD) transition and the effect of antibiotic-induced microbiota depletion (AIMD) on this transition.

Strain-Insensitive Outdoor Wearable Electronics by Thermally Robust Nanofibrous Radiative Cooler

Strain-Insensitive Outdoor Wearable Electronics by Thermally Robust Nanofibrous Radiative Cooler

Prof. Seung Hwan Ko

Stable outdoor wearable electronics are gaining attention due to challenges in sustaining consistent device performance outdoors, where sunlight exposure and user movement can disrupt operations.

Discovery of Terminal Oxazole-Bearing Natural Products by a Targeted Metabologenomic Approach

Discovery of Terminal Oxazole-Bearing Natural Products by a Targeted Metabologenomic Approach

Prof. Dong-Chan Oh

A targeted metabologenomic method was developed to selectively discover terminal oxazole-bearing natural products from bacteria. For this, genes encoding oxazole cyclase, a key enzyme in terminal oxazole biosynthesis, were chosen as the genomic signature to screen bacterial strains that may produce oxazole-bearing compounds.

Disruption of G-quadruplex dynamicity by BRCA2 abrogation instigates phase separation and break-induced replication at telomeres

Disruption of G-quadruplex dynamicity by BRCA2 abrogation instigates phase separation and break-induced replication at telomeres

Prof. Hyunsook Lee

Dynamic interaction between BRCA2 and telomeric G-quadruplexes (G4) is crucial for maintaining telomere replication homeostasis. Cells lacking BRCA2 display telomeric damage with a subset of these cells bypassing senescence to initiate break-induced replication (BIR) for telomere synthesis.

Phytohormonal regulation determines the organization pattern of shoot aerenchyma in greater duckweed (<i>Spirodela polyrhiza</i>)

Phytohormonal regulation determines the organization pattern of shoot aerenchyma in greater duckweed (Spirodela polyrhiza)

Prof. Daehee Hwang and Yuree Lee

Airspace or aerenchyma is crucial for plant development and acclimation to stresses such as hypoxia, drought, and nutritional deficiency. Although ethylene-mediated signaling cascades are known to regulate aerenchyma formation in stems and roots under hypoxic conditions, the precise mechanisms remain unclear.