Glioblastoma recurs despite surgery, with poor survival (~1 year). Our study reveals neural stem cells in the subventricular zone (SVZ) as the origin of recurrence. Genomic analysis confirmed SVZ-derived cancer-initiating cells drive relapse. Blocking CXCR4 reduced recurrence and improved survival by 60-70%, offering a new therapeutic strategy.

As an animal matures, its neural circuit undergoes alterations, yet the developmental changes in intracellular organelles to facilitate these changes is less understood.

RAS/MAPK pathway mutations often induce RASopathies with overlapping features, such as craniofacial dysmorphology, cardiovascular defects, dermatologic abnormalities, and intellectual disabilities. Although BRAF gene mutations are associated with cardio-facio-cutaneous (CFC) syndrome and Noonan syndrome, it remains unclear how these mutations impair cognition.

College of Engineering at Seoul National University announced that a research team led by Professor Gwan-Hyoung Lee from the Department of Materials Science and Engineering, in collaboration with the research teams of Professors Hyejin Jang and Jeong Woo Han from the same department, has successfully developed the new synthesis technology of 2D semiconductors.

Professor Jooli Han from the Department of Biomedical Engineering at SNU College of Medicine has developed a reliable on-patient medical record and mRNA vaccine delivery system using deep learning and intradermal microneedles.

Seoul National University College of Engineering announced that Professor Jungwon Park’s research team from the Department of Chemical and Biological Engineering has developed a groundbreaking technology to observe atomic structural changes of nanoparticles in three dimensions.

Professor Jong-seong Kug’s research team from School of Earth and Environmental Sciences at SNU revealed that the permafrost ecosystem carbon loss may continue under net-zero and negative emissions, which could hinder climate change mitigation efforts.

We are currently facing a global climate crisis of unparalleled scope and scale. The human role in this is clear – we are a key factor in the changes on our planet. In recent years climate scientists have been terming this new era the Anthropocene, to denote the human (‘anthropos’) driver of change.

Professor Joonghoon Park's research team identified celecoxib as a small-molecule PROKR1 agonist that enhances muscle mass and strength. Mice imprinted with celecoxib maintained increased oxidative muscle fibers and improved metabolism even on a high-fat diet. This study is the first to discover a selective PROKR1 small-molecule agonist, providing a new drug scaffold for sarcopenia and obesity treatment and laying the foundation for drug development.

Machine learning interatomic potentials (MLIPs) promise quantum-level accuracy at classical force field speeds, but their performance hinges on the quality and diversity of training data.

Professor Martin Steinegger’s research team from the Department of Biological Sciences at Seoul National University and Professor Emmanuel D. Levy’s research team from the Department of Molecular Biology and Cellular Biology at University of Geneva have successfully developed a rapid and sensitive protein complex structural aligner, enabling the comparison of billions of complex pairs within just 11 hours.

Seoul National University College of Engineering announced that a research team led by Professor Kyu-Jin Cho (Director of the Soft Robotics Research Center) from the Department of Mechanical Engineering took inspiration from principles found in nature and developed the "Hyperelastic Torque Reversal Mechanism (HeTRM)," which enables robots made from rubber-like soft materials to perform rapid and powerful movements.