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Research Highlights

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Research Highlights

Temporally Distinct 3D Multi-Omic Dynamics in the Developing Human Brain

Temporally Distinct 3D Multi-Omic Dynamics in the Developing Human Brain

Prof. Dong-Sung Lee

Professor Dongsung Lee from the College of Medicine at SNU, in collaboration with researchers at UCLA and UCSF, has published a paper in Nature, being the first in the world to study epigenomic changes, including the three-dimensional genome structure and DNA methylation, during human brain development from the fetal stage to adulthood at the single-cell level, using the single-nucleus methyl-3C technology they developed.

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Discovery of Highly Active Kynureninases for Cancer Immunotherapy through Protein Language Model

Discovery of Highly Active Kynureninases for Cancer Immunotherapy through Protein Language Model

Prof. Woon Ju Song and Martin Steinegger

Tailor-made enzymes empower a wide range of versatile applications, although searching for the desirable enzymes often requires high throughput screening and thus poses significant challenges. In this study, we employed homology searches and protein language models to discover and prioritize enzymes by their kinetic parameters.

Cerebellar Bergmann glia integrate noxious information and modulate nocifensive behaviors

Cerebellar Bergmann glia integrate noxious information and modulate nocifensive behaviors

Prof. Sang Jeong Kim

The cerebellum is activated by noxious stimuli and pathological pain but its role in noxious information processing remains unknown.

Induction of Oral Lichen Planus-Like Histopathology in Mice

Induction of Oral Lichen Planus-Like Histopathology in Mice

Prof. Youngnim Choi

Oral lichen planus (OLP) is a chronic T cell-mediated inflammatory mucosal disease of unknown etiology. The lack of suitable animal models has hampered understanding its etiopathogenesis.

Impaired chaperone-mediated autophagy leads to abnormal SORT1 (sortilin 1) turnover and CES1-dependent triglyceride hydrolysis

Impaired chaperone-mediated autophagy leads to abnormal SORT1 (sortilin 1) turnover and CES1-dependent triglyceride hydrolysis

Prof. Byung-Hoon Lee

SORT1 (sortilin 1), a member of the the Vps10 (vacuolar protein sorting 10) family, is involved in hepatic lipid metabolism by regulating very low-density lipoprotein (VLDL) secretion and facilitating the lysosomal degradation of CES1 (carboxylesterase 1), crucial for triglyceride (TG) breakdown in the liver.

Genome-wide phenotypic profiling of transcription factors and identification of novel targets to control the virulence of <i>Vibrio vulnificus</i>

Genome-wide phenotypic profiling of transcription factors and identification of novel targets to control the virulence of Vibrio vulnificus

Prof. Sang Ho Choi

Professor Choi’s research team at SNU has identified the Vibrio vulnificus transcription factors at a genome-wide scale and characterized their functions comprehensively, proposing novel targets to control the pathogen.

Dual function of PHF16 in reinstating homeostasis of murine intestinal epithelium after crypt regeneration

Dual function of PHF16 in reinstating homeostasis of murine intestinal epithelium after crypt regeneration

Prof. Sung Hee Baek

Professor Sunghee Baek's team at SNU identified PHF16 as key to intestinal homeostasis after injury. PHF16 restores the epithelium by activating RAR/RXR target genes via HBO1 histone acetylation and suppressing YAP/TAZ via CDC73 ubiquitination. Its role offers insights for gut repair therapies.

A Natural Laboratory for Astrochemistry: The Variable Protostar B335

A Natural Laboratory for Astrochemistry: The Variable Protostar B335

Prof. Jeong-Eun Lee

Emission lines from complex organic molecules in B335 were observed in four epochs, spanning a luminosity burst of about 10 years duration. The emission lines increased dramatically in intensity as the luminosity increased, but they have decreased only slightly as the luminosity has decreased.

Neuroplasticity-enhancing therapy using glia-like cells derived from human mesenchymal stem cells for the recovery of sequelae of cerebral infarction

Neuroplasticity-enhancing therapy using glia-like cells derived from human mesenchymal stem cells for the recovery of sequelae of cerebral infarction

Prof. Mi-Sook Chang

Despite a dramatic increase in ischemic stroke incidence worldwide, effective therapies for attenuating sequelae of cerebral infarction are lacking. This study investigates the use of human mesenchymal stem cells (hMSCs) induced toward glia-like cells (ghMSCs) to ameliorate chronic sequelae resulting from cerebral infarction.

Structural insight into the distinct regulatory mechanism of the HEPN-MNT toxin-antitoxin system in <i>Legionella pneumophila</i>

Structural insight into the distinct regulatory mechanism of the HEPN-MNT toxin-antitoxin system in Legionella pneumophila

Prof. Byung Woo Han

HEPN-MNT, a type VII TA module, comprises the HEPN toxin and the MNT antitoxin, which acts as a nucleotidyltransferase that transfers the NMP moiety to the corresponding HEPN toxin, thereby interfering with its toxicity.

Calcium ion-triggered liquid-liquid phase separation of silk fibroin and spinning through acidification and shear stress

Calcium ion-triggered liquid-liquid phase separation of silk fibroin and spinning through acidification and shear stress

Prof. Ki Hoon Lee

Professor Ki Hoon Lee's research team from the Department of Agriculture, Forestry, and Bioresources at SNU developed a biomimetic spinning process by leveraging silk fibroin's liquid-liquid phase separation, followed by acidification and shear force to produce fibers.

Conserved effector families render <i>Phytophthora</i> species vulnerable to recognition by NLR receptors in nonhost plants

Conserved effector families render Phytophthora species vulnerable to recognition by NLR receptors in nonhost plants

Prof. Doil Choi

Prof. Doil Choi and research team identified multiple resistance genes against various Phytophthora pathogens that threat wide-range of important crop species

Professor Seung Hwan Ko's Research Team at Seoul National University Develops Filter-Free Microbubble Air Purification System

Professor Seung Hwan Ko's Research Team at Seoul National University Develops Filter-Free Microbubble Air Purification System

Professor Seung Hwan Ko

Seoul National University College of Engineering announced that a research team led by Professor Seung Hwan Ko from the Department of Mechanical Engineering has developed an eco-friendly air purification system using microbubble filters instead of conventional solid filters.