Research Highlights - Research Highlights - Research - Seoul National University

Skip to content

Research / Research Highlights

Research Highlights

Research Highlights /

Research Highlights

Temporally Distinct 3D Multi-Omic Dynamics in the Developing Human Brain

Temporally Distinct 3D Multi-Omic Dynamics in the Developing Human Brain

Prof. Dong-Sung Lee

Professor Dongsung Lee from the College of Medicine at SNU, in collaboration with researchers at UCLA and UCSF, has published a paper in Nature, being the first in the world to study epigenomic changes, including the three-dimensional genome structure and DNA methylation, during human brain development from the fetal stage to adulthood at the single-cell level, using the single-nucleus methyl-3C technology they developed.

Read more >

Celecoxib Enhances Oxidative Muscle Fibre Formation and Improves Muscle Functions Through Prokr1 Activation in Mice

Celecoxib Enhances Oxidative Muscle Fibre Formation and Improves Muscle Functions Through Prokr1 Activation in Mice

Prof. Joonghoon Park

Professor Joonghoon Park's research team identified celecoxib as a small-molecule PROKR1 agonist that enhances muscle mass and strength. Mice imprinted with celecoxib maintained increased oxidative muscle fibers and improved metabolism even on a high-fat diet. This study is the first to discover a selective PROKR1 small-molecule agonist, providing a new drug scaffold for sarcopenia and obesity treatment and laying the foundation for drug development.

Automated and Efficient Sampling of Chemical Reaction Space

Automated and Efficient Sampling of Chemical Reaction Space

Prof. Juyong Lee

Machine learning interatomic potentials (MLIPs) promise quantum-level accuracy at classical force field speeds, but their performance hinges on the quality and diversity of training data.

Rapid and Sensitive Protein Complex Alignment with Foldseek-Multimer

Rapid and Sensitive Protein Complex Alignment with Foldseek-Multimer

Prof. Martin Steinegger

Professor Martin Steinegger’s research team from the Department of Biological Sciences at Seoul National University and Professor Emmanuel D. Levy’s research team from the Department of Molecular Biology and Cellular Biology at University of Geneva have successfully developed a rapid and sensitive protein complex structural aligner, enabling the comparison of billions of complex pairs within just 11 hours.

Professor Kyu-Jin Cho's Research Team at Seoul National University Applies the Principles of Mantis Shrimp and Fleas to Create Soft Robots with Powerful Movements

Professor Kyu-Jin Cho's Research Team at Seoul National University Applies the Principles of Mantis Shrimp and Fleas to Create Soft Robots with Powerful Movements

Prof. Kyu-Jin Cho

Seoul National University College of Engineering announced that a research team led by Professor Kyu-Jin Cho (Director of the Soft Robotics Research Center) from the Department of Mechanical Engineering took inspiration from principles found in nature and developed the "Hyperelastic Torque Reversal Mechanism (HeTRM)," which enables robots made from rubber-like soft materials to perform rapid and powerful movements.

Regulation of senescence-associated secretory phenotypes in osteoarthritis by cytosolic UDP-GlcNAc retention and O-GlcNAcylation

Regulation of senescence-associated secretory phenotypes in osteoarthritis by cytosolic UDP-GlcNAc retention and O-GlcNAcylation

Prof. Jin-Hong Kim

Professor Jin-Hong Kim's research team from School of Biological Sciences at SNU identified the pathogenic role of sugar modification which governs the senescence-associated secretory phenotype in cartilage, and proposed targeting GATA4 O-GlcNAcylation as a senostatic strategy for osteoarthritis.

Isoxazole-based molecules restore NK cell immune surveillance in hepatocarcinogenesis by targeting TM4SF5 and SLAMF7 linkage

Isoxazole-based molecules restore NK cell immune surveillance in hepatocarcinogenesis by targeting TM4SF5 and SLAMF7 linkage

Prof. Jung Weon Lee

Dynamic communication between hepatocytes and the environment is critical in hepatocellular carcinoma (HCC) development. Clinical immunotherapy against HCC is currently unsatisfactory and needs more systemic considerations, including the identification of new biomarkers and immune checkpoints.

Passive and active suppression of transduced noise in silicon spin qubits

Passive and active suppression of transduced noise in silicon spin qubits

Prof. Dohun Kim

Professor Dohun Kim's research team from the Department of Physics and Astronomy at SNU has successfully developed two techniques to suppress noise and its effects, which hinder high-fidelity quantum operations. Using these methods, they achieved a two-fold improvement in inhomogeneous coherence time and a ten-fold improvement in the quality of Rabi oscillations.

Professor Seung-Kyun Kang's Research Team at Seoul National University Developed the World’s Most Sensitive Flexible Strain Sensor

Professor Seung-Kyun Kang's Research Team at Seoul National University Developed the World’s Most Sensitive Flexible Strain Sensor

Prof. Seung-Kyun Kang

Seoul National University College of Engineering announced that a research team led by Prof. Seung-Kyun Kang from the Department of Materials Science and Engineering at Seoul National University (first authors: Dr. Jae-Hwan Lee and Ph.D. candidate Yoon-Nam Kim) has developed a strain sensor with record-breaking sensitivity in collaboration with researchers from Dankook University, Ajou University, and Purdue University.

Mutually antagonistic molecular clips: symmetry-breaking non-covalent bonds at the chiral–nonchiral interface

Mutually antagonistic molecular clips: symmetry-breaking non-covalent bonds at the chiral–nonchiral interface

Prof. Dongwhan Lee

The homochirality of life remains an unresolved scientific question. Prevailing models postulate that homochirality arose through mutual antagonism. In this mechanism, molecules of opposite handedness deactivate each other, amplifying even a small enantiomeric excess into a larger proportion.

SNU-Hyundai Motor Group Jointly Develop Advanced Technology for Evaluating Fuel Cell Catalyst Durability and Degradation Mechanisms

SNU-Hyundai Motor Group Jointly Develop Advanced Technology for Evaluating Fuel Cell Catalyst Durability and Degradation Mechanisms

Prof. Jungwon Park and Jaeyune Ryu

The College of Engineering at Seoul National University announced that Professors Jungwon Park and Jaeyune Ryu of the Department of Chemical and Biological Engineering, in collaboration with Hyundai Motor Group, have developed an innovative technology for rapid durability assessment and identification of degradation mechanisms of hydrogen fuel cell catalysts.

Compositional Optimization for Miticidal Activity, Ecotoxicity, and Phytotoxicity of <i>Rosmarinus officinalis</i> Essential Oils as Biorational Pesticides

Compositional Optimization for Miticidal Activity, Ecotoxicity, and Phytotoxicity of Rosmarinus officinalis Essential Oils as Biorational Pesticides

Prof. Jun-Hyung Tak

The SNU CALS team, led by Prof. Jun-Hyung Tak, has presented a framework to optimize the composition of natural product-based pesticides, maximizing pesticidal activity while minimizing undesirable effects such as ecotoxicity and phytotoxicity.

Discovery of Highly Active Kynureninases for Cancer Immunotherapy through Protein Language Model

Discovery of Highly Active Kynureninases for Cancer Immunotherapy through Protein Language Model

Prof. Woon Ju Song & Prof. Martin Steinegger

Overcoming the immunosuppressive tumor microenvironment is a promising strategy in anticancer therapy. L-kynurenine, a strong immunosuppressive metabolite can be degraded through kynureninases.