Research Highlights - Research Highlights - Research - Seoul National University

Skip to content

Research / Research Highlights

Research Highlights

Research Highlights /

Research Highlights

Temporally Distinct 3D Multi-Omic Dynamics in the Developing Human Brain

Temporally Distinct 3D Multi-Omic Dynamics in the Developing Human Brain

Prof. Dong-Sung Lee

Professor Dongsung Lee from the College of Medicine at SNU, in collaboration with researchers at UCLA and UCSF, has published a paper in Nature, being the first in the world to study epigenomic changes, including the three-dimensional genome structure and DNA methylation, during human brain development from the fetal stage to adulthood at the single-cell level, using the single-nucleus methyl-3C technology they developed.

Read more >

Seoul National University

Opportunistic AI for enhanced cardiovascular disease risk stratification using abdominal CT scans

Prof. Sang Min Park

This study introduces the Deep Learning-based Cardiovascular Disease Incident (DL-CVDi) score, a novel biomarker derived from routine abdominal CT scans, optimized to predict cardiovascular disease (CVD) risk using deep survival learning.

Cell enlargement modulated by GATA4 and YAP instructs the senescence-associated secretory phenotype

Cell enlargement modulated by GATA4 and YAP instructs the senescence-associated secretory phenotype

Prof. Chanhee Kang

Senescent cells-a key component of aging-exhibit cell enlargement, the function of which has been unclear for decades. Professor Chanhee Kang’s research team from School of Biological Sciences at SNU identify a antagonistic genetic circuit for senescent hypertrophy and its instructive role in modulating the senescence-associated secretory phenotype (SASP).

Miniature Li<sup>+</sup> solvation by symmetric molecular design for practical and safe Li-metal batteries

Miniature Li⁺ solvation by symmetric molecular design for practical and safe Li-metal batteries

Prof. Jiheong Kang

Developing high-safety Li-metal batteries (LMBs) with rapid rechargeability represents a crucial avenue for the widespread adoption of electrochemical energy storage devices. Realization of LMBs requires an electrolyte that combines non-flammability with high electrochemical stability.

SlH3 and SlH4 promote multicellular Trichome formation and elongation by upregulating woolly in tomato

SlH3 and SlH4 promote multicellular Trichome formation and elongation by upregulating woolly in tomato

Prof. Jin-Ho Kang

Trichomes are tiny outgrowths on the plant epidermis that serve defensive purposes against various stresses. While the regulatory mechanisms underlying unicellular trichome development are well understood, those governing multicellular trichome formation remain largely unexplored.

Seoul National University

Extracellular vesicles of Limosilactobacillus fermentum SLAM216 ameliorate skin symptoms of atopic dermatitis by regulating gut microbiome on serotonin metabolism

Prof. Younghoon Kim

Atopic dermatitis (AD) is a globally prevalent chronic inflammatory skin disorder. Its pathogenesis remains incompletely understood, resulting in considerable therapeutic challenges. Recent studies have highlighted the significance of the interaction between AD and gut microbiome.

Seoul National University

Identification of a new bovine picornavirus (Boosepivirus) in the Republic of Korea

Prof. Joon-Seok Chae

This is the first study to determine the prevalence and molecular characteristics of BooV in calf diarrhea in the ROK, highlighting the potential importance of BooV as a causative agent of calf diarrhea and highlighting the need for further research on its epidemiology and pathogenicity.

SARS-CoV-2 pseudovirus dysregulates hematopoiesis and induces inflammaging of hematopoietic stem and progenitor cells

SARS-CoV-2 pseudovirus dysregulates hematopoiesis and induces inflammaging of hematopoietic stem and progenitor cells

Prof. Kyung-Rok Yu

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection primarily affects the respiratory system but may induce hematological alterations such as anemia, lymphopenia and thrombocytopenia. Previous studies have reported that SARS-CoV-2 efficiently infects hematopoietic stem and progenitor cells (HSPCs); however, the subsequent effects on hematopoiesis and immune reconstitution have not yet been described.

Contributing factors to the length of stay and discharge destination of home health care patients: 10-year electronic health record analysis using the Donabedian model

Contributing factors to the length of stay and discharge destination of home health care patients: 10-year electronic health record analysis using the Donabedian model

Prof. Kyungmi Woo

Professor Kyungmi Woo’s research team from the College of Nursing at Seoul National University has conducted a comprehensive 10-year analysis of home health care patients using electronic health records. The study identified key factors influencing the length of stay and discharge destination, highlighting the critical role of nursing process variables such as visit frequency, nursing service and patient’s insurance type.

Distant origin of glioblastoma recurrence: neural stem cells in the subventricular zone serve as a source of tumor reconstruction after primary resection

Distant origin of glioblastoma recurrence: neural stem cells in the subventricular zone serve as a source of tumor reconstruction after primary resection

Prof. Joo Ho Lee

Glioblastoma recurs despite surgery, with poor survival (~1 year). Our study reveals neural stem cells in the subventricular zone (SVZ) as the origin of recurrence. Genomic analysis confirmed SVZ-derived cancer-initiating cells drive relapse. Blocking CXCR4 reduced recurrence and improved survival by 60-70%, offering a new therapeutic strategy.

Structural diversity of mitochondria in the neuromuscular system across development revealed by 3D electron microscopy

Structural diversity of mitochondria in the neuromuscular system across development revealed by 3D electron microscopy

Prof. Junho Lee

As an animal matures, its neural circuit undergoes alterations, yet the developmental changes in intracellular organelles to facilitate these changes is less understood.

Aberrant ERK signaling in astrocytes impairs learning and memory in RASopathy-associated <i>BRAF</i> mutant mouse models

Aberrant ERK signaling in astrocytes impairs learning and memory in RASopathy-associated BRAF mutant mouse models

Prof. Yong-Seok Lee

RAS/MAPK pathway mutations often induce RASopathies with overlapping features, such as craniofacial dysmorphology, cardiovascular defects, dermatologic abnormalities, and intellectual disabilities. Although BRAF gene mutations are associated with cardio-facio-cutaneous (CFC) syndrome and Noonan syndrome, it remains unclear how these mutations impair cognition.

Professor Gwan-Hyoung Lee's Research Team at Seoul National University Develops a New Synthesis Technology of Single Crystal 2D Semiconductors, “Hypotaxy”, to Enhance the Commercialization of Next-Generation 2D Semiconductors

Professor Gwan-Hyoung Lee's Research Team at Seoul National University Develops a New Synthesis Technology of Single Crystal 2D Semiconductors, “Hypotaxy”, to Enhance the Commercialization of Next-Generation 2D Semiconductors

Professor Gwan-Hyoung Lee

College of Engineering at Seoul National University announced that a research team led by Professor Gwan-Hyoung Lee from the Department of Materials Science and Engineering, in collaboration with the research teams of Professors Hyejin Jang and Jeong Woo Han from the same department, has successfully developed the new synthesis technology of 2D semiconductors.