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Research Highlights

Research Highlights /

Research Highlights

Temporally Distinct 3D Multi-Omic Dynamics in the Developing Human Brain

Temporally Distinct 3D Multi-Omic Dynamics in the Developing Human Brain

Prof. Dong-Sung Lee

Professor Dongsung Lee from the College of Medicine at SNU, in collaboration with researchers at UCLA and UCSF, has published a paper in Nature, being the first in the world to study epigenomic changes, including the three-dimensional genome structure and DNA methylation, during human brain development from the fetal stage to adulthood at the single-cell level, using the single-nucleus methyl-3C technology they developed.

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Epitaxially Strained CeO2/Mn3O4 Nanocrystals as an Enhanced Antioxidant for Radioprotection

Epitaxially Strained CeO2/Mn3O4 Nanocrystals as an Enhanced Antioxidant for Radioprotection

Prof. Taeghwan Hyeon, Prof. Kyungpyo Park

Nanomaterials with antioxidant properties are promising for treating reactive oxygen species (ROS)-related diseases. However, maintaining efficacy at low doses to minimize toxicity is a critical for clinical applications.

Decadal Changes in Meridional Overturning Circulation in the East Sea (Sea of Japan)

Decadal Changes in Meridional Overturning Circulation in the East Sea (Sea of Japan)

Prof. SUNGHYUN NAM

Meridional overturning circulation (MOC) is vital to distributing heat, freshwater, and dissolved matter in semienclosed deep marginal seas such as the East Sea (ES) (Sea of Japan). As our understanding of the ES MOC remains incomplete, we attempted to fill this research gap. We analyzed the ES MOC and its decadal chan...

Chemical RNA digestion enables robust RNA-binding site mapping at single amino acid resolution

Chemical RNA digestion enables robust RNA-binding site mapping at single amino acid resolution

School of Biological Sciences V. Narry Kim, Jong-Seo Kim

Abstract RNA-binding sites (RBSs) can be identified by liquid chromatography and tandem mass spectrometry analyses of the protein–RNA conjugates created by crosslinking, but RBS mapping remains highly challenging due to the complexity of the formed RNA adducts. Here, we introduce RBS-ID, a method that uses hydrofluorid...

Causal mechanism of injection-induced earthquakes through the Mw 5.5 Pohang earthquake case study

Causal mechanism of injection-induced earthquakes through the Mw 5.5 Pohang earthquake case study

Prof. Lee, KangKun, School of Earth and Environmental Sciences

Causal mechanisms for fluid injection-induced earthquakes remain a challenge to identify. Past studies largely established spatiotemporal correlations. Here, we propose a multi-process causal mechanism for injection-induced earthquakes through a case study of the 2017 Mw 5.5 induced earthquake near Pohang Enhanced Geot...

Modeling and Simulation of a Fully-glycosylated Full-length SARS-CoV-2 Spike Protein in a Viral Membrane

Modeling and Simulation of a Fully-glycosylated Full-length SARS-CoV-2 Spike Protein in a Viral Membrane

Prof. Chaok Seok

This technical study describes all-atom modeling and simulation of a fully-glycosylated fulllength SARS-CoV-2 spike (S) protein in a viral membrane. First, starting from PDB:6VSB and 6VXX, full-length S protein structures were modeled using template-based modeling, de-novo protein structure prediction, and loop modelin...

Immunostimulation by starch hydrogel-based oral vaccine using formalin-killed cells against edwardsiellosis in Japanese eel, Anguilla japonica

Immunostimulation by starch hydrogel-based oral vaccine using formalin-killed cells against edwardsiellosis in Japanese eel, Anguilla japonica

Prof. Se Chang Park

Graphene quantum dots as anti-inflammatory therapy for colitis

Graphene quantum dots as anti-inflammatory therapy for colitis

Prof. Kyung-Sun Kang

Abstract While graphene and its derivatives have been suggested as a potential nanomedicine in several biomimetic models, their specific roles in immunological disorders still remain elusive. Graphene quantum dots (GQDs) may be suitable for treating intestinal bowel diseases (IBDs) because of their low toxicity in vivo...

The stone-base illusion

The stone-base illusion

Prof. Songjoo Oh

Abstract A popular method used to construct the post structure in traditional Korean buildings is simply placing a stone base on the ground in the natural form and a wooden post on top of the stone base. Interestingly, an illusory visual completion often occurs at the joint where the stone base and the post join. Thus,...

A discrete core-shell-like micro-light-emitting diode array grown on sapphire nano-membranes

A discrete core-shell-like micro-light-emitting diode array grown on sapphire nano-membranes

Prof. Euijoon Yoon

Abstract A discrete core-shell-like micro-light-emitting diode (micro-LED) array was grown on a 100 nm-thick sapphire nano-membrane array without harmful plasma etching for chip singulation. Due to proper design for the sapphire nano-membrane array, an array of multi-faceted micro-LEDs with size of 4 μm × 16 μm was gro...

Critical differences in 3D atomic structure of individual ligand-protected nanocrystals in solution

Critical differences in 3D atomic structure of individual ligand-protected nanocrystals in solution

Prof. Jungwon Park

Seeing subtle nanoparticle differences A challenge in the fabrication of nanoparticles is that even for particles of uniform size, there will still be a distribution in the atomic arrangements and surface capping ligands from one particle to the next. Using liquid-cell transmission electron microscopy, Kim et al. recon...

Mitochondrial plastid DNA can cause DNA barcoding paradox in plants

Mitochondrial plastid DNA can cause DNA barcoding paradox in plants

Prof. Tae-Jin Yang

The transfer of ancestral plastid genomes into mitochondrial genomes to generate mitochondrial plastid DNA (MTPT) is known to occur in plants, but its impacts on mitochondrial genome complexity and the potential for causing a false-positive DNA barcoding paradox have been underestimated. Here, we assembled the organell...

Ladybird Beetle Inspired Compliant Origami

Ladybird Beetle Inspired Compliant Origami

Prof. Kyu-Jin Cho

Authors Sang-Min Baek, Sojung Yim, Soo-Hwan Chae, Dae-Young Lee, Kyu-Jin Cho Affiliations Soft Robotics Research Center, Seoul National University, Seoul, Republic of Korea. Department of Mechanical and Aerospace Engineering, Institute of Advanced Machines and Design, Seoul National University, Seoul, Republic of Korea...